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Sunday, 10 May 2020

Why Children Exhibit Mild Symptoms of Covid19


Melatonin is the reason why children under the age of 9 seldom exhibit severe symptoms. In fact, children may exhibit mild or even no symptoms at all, even though they have been infected by SARS-CoV-2 https://www.cdc.gov/coronavirus/2019-ncov/faq.html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fcoronavirus%2F2019-ncov%2Fprepare%2Fchildren-faq.html
 
Normally for most individuals peak melatonin production is between the hours of 2 am to 3 am.  The maximum melatonin levels measured in healthy adults between the ages of 65 to 70 years appeared to be around 49.3 picograms/ml (pg/ml).  Adults more than 75 years of age only have maximum production levels of 27.8 pg/ml .  https://pubmed.ncbi.nlm.nih.gov/27302542-physiological-melatonin-levels-in-healthy-older-people-a-systematic-review/
 
However young children, on the other hand, have extremely high melatonin levels, compared to adults.  The maximum levels recorded for children showed a decline as age increased. Children between the ages of 1 to 5 had peak melatonin at 325 pg/ml, while those between the ages of 5 to 11 already declined to 133 pg/ml . https://pubmed.ncbi.nlm.nih.gov/6141425-fall-in-nocturnal-serum-melatonin-during-prepuberty-and-pubescence/
 
When compared to healthy adult seniors, a young child can easily have TEN TIMES the amount of peak melatonin levels.  But even then, the actual physiological concentration is extremely low. What is the amount of one picogram:
 
To give one some an idea, most melatonin supplements are around 3 to 5 mg per capsule or tablet.  One milligram equals 1,000,000,000 picograms. That is why the physiological dosage generally recommended for melatonin supplementation is around 0.3 milligram https://pubmed.ncbi.nlm.nih.gov/15649738-melatonin-as-a-hypnotic-pro/
 
The significant fact that young children have such high melatonin levels explains why kids show very mild symptoms after COVID-19 infections.

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